Use Case:

Multi-Centre Local & Central Review

Impact of Positron Emission Tomography (PET) Imaging in Muscle-Invasive Urothelial Carcinoma of the Bladder Staging (PETMUSE)

(ClinicalTrials.gov Identifier: NCT02462239)

In this multi-centre trial, patients (n=291 from 6 centres) randomly receive a whole-body PET-CT scan to determine whether imaging assists in muscle-invasive urothelial carcinoma of the bladder staging. Each PET-CT scan needs to then be reviewed locally and centrally within 3-5 days of the scan.

QIPCM provided a de-identification and image transfer pipeline to each centre to anonymize all trial images before they leave each centre. Only anonymized images are sent to QIPCM, after which they are archived in our safe, secure, and backed-up PACS.

Access to these images are logged and made available only to permitted trial personnel. Central reviewers can thus log-in to the QIPCM platform to review trial images anytime, from anywhere with internet access to meet review deadlines.

Requirement	QIPCM Solution
Image Anonymization and Transfer from Multiple Institutions	Custom pipeline for de-identification and secure transfer from each institution to the QIPCM repository De-identification and image transfer pipeline provided for each site
Image QA	Image QA by QIPCM
Centralized Storage with Image Access Logs	Images that pass QA are forwarded to centralized PACS
Remote Connection (2-factor authentication)	QIPCM Virtual Desktop Infrastructure (VMs)
Software of Choice for Performing Central Review by Multiple Users	Installation of desired software onto user VMs

Collaborator

Referencing QIPCM in Your Publications

For publications resulting from our services, please acknowledge QIPCM in the Acknowledgements section of your manuscript.

Acknowledgements are an important reflection of our contributions to your published work, and help strengthen our applications for grant funding. We appreciate your acknowledgements!

In general, it is sufficient to reference qipcm.com and/or QIPCM for tracking and reporting purposes. It is not required that Individual team members be named unless they have made a direct scientific contribution to your work that warrants authorship or specific acknowledgement.
To support accurate tracking of core facility usage in publications, please include the following Research Resource Identifier (RRID)*:

– QIPCM – RRID: SCR_027527

* A Research Resource Identifier (RRID) is a unique citation code that enables transparent reporting and recognition of core facilities in published research.