Publications & Presentations

Presentations

OICR Imaging Open House – Quantitative Imaging for Personalized Cancer Medicine

Watch our recorded presentation at OICR Imaging Program Open House that showcased OICR’s collaborative research resources in the areas of molecular imaging and histopathology (IVC), image management and analysis tools for clinical trials (QIPCM), imaging radioprobe development (CPDC) and imaging instrumentation engineering (MIIS) capabilities.

Enhancing Cancer Research with Quantitative Imaging: A Deep Dive into QIPCM at UHN

Watch our recorded webinar showcasing the groundbreaking advancements and real-world applications of Quantitative Imaging for Personalized Cancer Medicine (QIPCM). Gain insights from our expert speakers as they delve into the capabilities of QIPCM and share detailed case studies illustrating its transformative effects.

Secure image data sharing in clinical trials and beyond.

Julia Publicover, MSc, PMP
Program Manager, Techna Institute, University Health Network

The QIPCM imaging core lab was conceived for high-quality, auditable and secure image management for clinical trials. More and more, users are looking to leverage the platform for large volume image analysis and processing, including radiomics and ML applications. This talk gave an overview of the QIPCM data-sharing platform including tools, services and quality management program that ensure high-quality image collection, analysis and regulatory compliance. I also discussed current use-cases in radiomics and ML and future aims.

Read the Full Presentation PDF

McGill Medical Physics Unit Seminar Series

This session had two presenters.
Speaker 1: Julia Publicover, M.Sc., PMP
Quantitative Imaging for Personalized Cancer Medicine (QIPCM), Techna Institute, University Health Network, Toronto, Ontario.

Title:
“UHN Molecular Imaging & Theranostics Pipeline”

Speaker 2: Ivan Yeung, Ph.D.
Associate Head, Department of Medical Physics, Princess Margaret Hospital, Toronto, Ontario.

Title:
“Multi-centre Phantom Study in Reproducibility of PET Radiomic Features”

Publications

NEWS ARTICLES

1. UHN Research & Innovation Cores Newsletter Article: QIPCM in the spotlight.

2. CENTRALIZED IMAGE MANAGEMENT for Multi-Centre Clinical Trial: Personalized cancer medicine seeks to identify the right therapy, for the right patient and at the right time. Imaging measurements are a key part of this personalization and need to be performed and analyzed with the highest level of precision and accuracy – this can include stratifying patients for appropriate treatment, designing image-guided treatments and evaluating response.

Read the full article by Julia Publicover featured at biotechnologyfocus.ca: View PDF Article

PEER-REVIEWED PUBLICATIONS

H K, Fyles A, Shek T, Croke J, Dhani N, D’Souza D, Lee T-Y, Chaudary N, Bruce J, Pintilie M, Carins R, Vines D, Pakbaz S, Jaffray D, Metser U, Rouzbahman M, Milosevic M, Koritzinsky M. 2022. A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer. Clinical Cancer Research.
Keller H, Shek T, Driscoll B, Xu, Y, Nghiem B, Nehmeh S, Grkovski M, Schmidtlein C R, Budzevich M, Balagurunathan Y, Sunderland J, Beichel R, Uribe C, Lee T-Y, Li F, Jaffray D, Yeung I. 2022. Noise-Based Image Harmonization Significantly Increases Repeatability and Reproducibility of Radiomics Features in PET Images: A Phantom Study. QIN Special Issue of Tomography.
Driscoll B, Shek T, Vines D, Sun A, Jaffray D, Yeung I. 2022. Phantom Validation of a Conservation of Activity-Based Partial Volume Correction Method for Arterial Input Function in Dynamic PET Imaging. QIN Special Issue of Tomography.
Gottwald J, Han K, Milosevic M, Yeung I, Jaffray D. 2022. Impact of PET scanner non-linearity on the estimation of hypoxic fraction in cervical cancer patients. Physica Medica.
Oliva M, Chepeha D, Araujo D, Diaz-Mejia J, Olson P, Prawira A, Spreafico A, Bratman S, Shek T, de Almeida J, Hansen A, Hope A, Goldstein D, Weinreb I, Smith S, Perez-Ordoñez B, Irish J, Torti D, Bruce J, Wang B, Fortuna A , Pugh T, Der-Torossian H, Shazer R, Attanasio N, Au Q,Tin A, Feeney J, Sethi H, Aleshin A, Chen I, Siu L. 2021. Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study. Journal for Immunotherapy of Cancer.
Elamir A, Stanescu T, Shessel A, Tadic T, Yeung I, Letourneau D, Kim J, Lukovic J, Dawson L, Wong R, Barry A, Brierly J, Gallinger S, Knox J , O’Kane G , Dhani N, Hosni A, Taylor E. 2021. Simulated dose painting of hypoxic sub-volumes in pancreatic cancer stereotactic body radiotherapy. Physics in Medicine and Biology.
Sanmamed N, Lee J, Berlin A, Craig T, Lao B, Rink A, Bayley A, Catton C, Sundaramurthy A, Foltz W, McPartlin A, Ghai S, Gospodarowicz M, Warde P, Menard C, Chung P. 2020. Tumor-targeted Dose Escalation for Localized Prostate Cancer using MR-guided HDR Brachytherapy (HDR) or Integrated VMAT (IB-VMAT) Boost: Dosimetry, Toxicity and Health Related Quality of Life. Radiother Oncol.
Driscoll B, Vines D, Shek T, Publicover J, Yeung I, Breen S, Jaffray D. 2020. 4D-CT Attenuation Correction in Respiratory-Gated PET for Hypoxia Imaging: Is It Really Beneficial? QIN Special Issue of Tomography.
Jones M, Hruby G, Coolens C, Driscoll B, Stanwell P, Kumar M, Capp A, Sridharan S, Arm J, Gallagher S, Holder C, Oldmeadow C, Martin J. 2020. A prospective, multi-centre trial of multi-parametric MRI as a biomarker in anal carcinoma. Radiotherapy and Oncology
Fiset S, Welch ML, Weiss J, Pintilie M, Conway JL, Milosevic M, Fyles A, Traverso A, Jaffray D, Metser U, Xie J, Han K. 2019. Repeatability and reproducibility of MRI-based radiomic features in cervical cancer. Radiotherapy and Oncology.
Traverso A, Kazmierski M, Shi Z, Kalendralis P, Welch M, Nissen HD, Jaffray D, Dekker A, Wee L. 2019. Stability of radiomic features of apparent diffusion coefficient (ADC) maps for locally advanced rectal cancer in response to image pre-processing. Physica Medica.
Welch ML, McIntosh C, Haibe-Kains B, Milosevic MF, Wee L, Dekker A, Huang SH, Purdie TG, O’Sullivan B, Aerts HJWL, Jaffray D. 2019. Vulnerabilities of radiomic signature development: The need for safeguards. Radiotherapy and Oncology.
Foltz W, Driscoll B, Lee S, Nayak K, Nallapareddy N, Fatemi A, Ménard C, Coolens C, Chung C. 2019. Phantom Validation of DCE-MRI Magnitude and Phase-Based Vascular Input Function Measurements. QIN Special Issue of Tomography.
Svistoun I, Driscoll B, Coolens C. 2019. Accuracy and Performance of Functional parameter estimation using a Novel Numerical Optimization Approach for GPU-Based Kinetic Compartmental Modeling. QIN Special Issue of Tomography.
Horie M, Levy L, Houbois C, Salazar P, Saito T, Pakkal M., O’Brien C, Sajja S, Brock K, Yasufuku K, Keshavjee S, Paul N, Martinu T. 2019. Lung Density Analysis Using Quantitative Chest CT for Early Prediction of Chronic Lung Allograft Dysfunction, Journal of Transplantation.
Tau N, Berlin A, Yeung I, Halankar J, Murphy G, Jhaveri KS, Ghai S, Metser U. 2019. Quantitative assessment of dynamic (18)F-flumethycholine PET and dynamic contrast enhanced MRI in high risk prostate cancer. Br J Radiol.
Press R, Shu H, Shim H, Mountz J, Kurland B, Wahl R, Jones E, Hylton N, Gerstner E, Nordstrom R, Henderson L, Kurdziel K, Vikram B, Jacobs M, Holdhoff M, Taylor E, Jaffray D, Schwartz L, Mankoff D, Kinahan P, Linden H, Lambin P, Dilling T, Rubin D, Hadjiiski L, Buatti J. 2018. The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective. International Journal of Radiation Oncology *Biology* Physics.
Coolens C, Mohseni H, Dhodi S, Ma S, Keller H, Jaffray D. 2018. Quantification accuracy for dynamic contrast enhanced (DCE) CT imaging: phantom and quality assurance framework. Eur J Radiol.
Jaffray D, Das S, Jacobs PM, Jeraj R, Lambin P. 2018. How advances in imaging will affect precision radiation oncology. International Journal of Radiation Oncology *Biology* Physics.
Coolens C, Driscoll B, Foltz W, Svistoun I, Sinno N, Chung C. 2018. Unified platform for multimodal voxel-based analysis to evaluate tumour perfusion and diffusion characteristics before and after radiation treatment evaluated in metastatic brain cancer. Br J Radiol.
Elhalawani E, Ger R, Mohamed A, Awan M, Ding Y, Li K, Fave X, Beers A, Driscoll B, Hormuth D II, van Houdt P, He R, Zhou S, Mathieu K, Li H, Coolens C, Chung C, Bankson J, Huang W, Wang J, Sandulache V, Lai S, Howell R, Stafford R, Yankeelov T, van der Heide U, Frank S, Barboriak D, Hazle J, Court L, Kalpathy-Cramer J, Fuller C. 2018. Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Head and Neck Cancers. Sci Data.
Han K, Shek T, Vines D, Driscoll B, Fyles A, Jaffray D, Keller H, Metser U, Pintilie M, Xie J, Yeung I, Milosevic M. 2018. Measurement of Tumor Hypoxia in Patients with Locally Advanced Cervical Cancer using Positron Emission Tomography (PET) with 18FFluoroazomyin Arabinoside (18F-FAZA). International Journal of Radiation Oncology *Biology* Physics.
Nehmeh SA, Schwartz J, Grkovski M, Yeung I, Laymon CM, Muzi M, Humm JL. 2018. Inter-operator variability in compartmental kinetic analysis of (18)F-fluoromisonidazole dynamic PET. Clinical Imaging.
Lee S, Lee J, Craig T, Berlin A, Chung P, Menard C, Foltz W. 2018. Changes in apparent diffusion coefficient radiomics features during dose-painted radiotherapy and high dose rate brachytherapy for prostate cancer. Physics and Imaging in Radiation Oncology.
Joint Head and Neck Radiotherapy-MRI Development Cooperative (QIPCM members: Driscoll B and Coolens C). 2017. A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations. Scientific Reports.
Gabrani-Juma H, Clarkin O, Pourmoghaddas A, Driscoll B, Wells RG, deKemp RA, Klein R. 2017. Validation of a Multimodality Flow Phantom and Its Application for Assessment of Dynamic SPECT and PET Technologies. IEEE Transactions in Medical Imaging.
Coolens C, Driscoll B, Foltz W, Pellow C, Menard C, Chung C. 2016. Comparison of Voxel-Wise Tumor Perfusion Changes Measured With Dynamic Contrast- Enhanced (DCE) MRI and Volumetric DCE CT in Patients With Metastatic Brain Cancer Treated with Radiosurgery. Tomography.
Han K, Croke J, Foltz W, Metser U, Xie J, Shek T, Driscoll B, Ménard C, Vines D, Coolens C, Simeonov A, Beiki-Ardakani A, Leung E, Levin W, Fyles A, Milosevic MF. 2016. A prospective study of DWI, DCE-MRI and FDG PET imaging for target delineation in brachytherapy for cervical cancer. Radiother Oncol.
Kalpathy-Cramer J, Mamomov A, Zhao B, Lu L, Cherezov D, Napel S, Echegaray S, Rubin D, McNitt-Gray M, Lo P, Sieren JC, Uthoff J, Dilger SK, Driscoll B, Yeung I, Hadjiiski L, Cha K, Balagurunathan Y, Gillies R, Goldgof D. 2016. Radiomics of Lung Nodules: A Multi-Institutional Study of Robustness and Agreement of Quantitative Imaging Features. Tomography.
Coolens C, Driscoll B, Moseley J, Brock KK, Dawson LA. 2016. Feasibility of 4D perfusion CT imaging for the assessment of liver treatment response following SBRT and sorafenib. Advances in Radiation Oncology.
Taylor E, Yeung I, Keller H, Wouters B, Milosevic M, Hedley D, Jaffray D. 2016. Quantifying hypoxia in human cancers using static PET imaging. Physics in Medicine and Biology.
Metran-Nascente C, Yeung I, Vines DC, Metser U, Dhani NC, Green D, Milosevic M, Jaffray D, Hedley DW. 2016. Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on 18F-Fluoroazomyin Arabinoside Uptake. Journal of Nuclear Medicine.
Milosevic MF, Townsley CA, Chaudary N, Clarke B, Pintilie M, Fan S, Glicksman R, Haider M, Kim S, MacKay H, Yeung I, Hill RP, Fyles A, Oza AM. 2016. Sorafenib Increases Tumor Hypoxia in Cervical Cancer Patients Treated With Radiation Therapy: Results of a Phase 1 Clinical Study. International Journal of Radiation Oncology *Biology* Physics.
Kim S, Haider M, Jaffray D, Yeung I. 2016. Improved accuracy of quantitative parameter estimates in dynamic contrast-enhanced CT study with low temporal resolution. Medical Physics.
Mera Iglesias M, Aramburu Núñez D, Del Olmo Claudio J, López Medina A, Landesa-Vázquez I, Salvador Gómez F, Driscoll B, Coolens C, Alba Castro JL, Muñoz V. 2015. Multimodality functional imaging in radiation therapy planning: relationships between dynamic contrast-enhanced MRI, diffusion-weighted MRI, and 18F-FDG PET. Comput Math Methods Med.
Jaffray D, Chung C, Coolens C, Foltz W, Keller H, Menard C, Milosevic M, Publicover J, Yeung I. 2015. Quantitative Imaging in Radiation Oncology: An Emerging Science and Clinical Service. Seminars in Radiation Oncology.
Coolens C, Driscoll B, Chung C, Shek T, Gorjizadeh A, Ménard C, Jaffray D. 2015. Automated Voxel-Based Analysis of Volumetric Dynamic Contrast-Enhanced CT Data Improves Measurement of Serial Changes in Tumor Vascular Biomarker. International Journal of Radiation Oncology *Biology* Physics.