Use Case:
Multi-Centre, Central Contouring Personalized Dosimetry
Lu-DOTATATE Treatment in Patients with 68Ga-DOTATATE Somatostatin Receptor Positive Neuroendocrine Tumors
In this multi-centre trial, each patient (n=195 from 4 centres) can receive up to 4 cycles of Lutetium-Dotatate (177Lu-Dota) therapy for neuroendocrine tumors (NETs). Prior to enrollment, patients receive a Gallium-68 SPECT-CT scan that must be reviewed by a tumor board to determine eligibility†.
The PI requested the ability to anonymize, send, and review images. In addition, to be able to contour tumors and create a cycle-to-cycle dosimetry report as therapy continues.
For enrolled patients, SPECT-CT images are collected by QIPCM at every cycle of 177Lu-Dota therapy using the QIPCM-issued image de-identification and transfer pipeline. Specified delegates were granted permission to view and contour this trial’s images on the QIPCM platform. QIPCM developed an extended workflow in MIM software so that physicians can themselves draw and process contours to generate dosimetry reports in PDF format. Each report can then be reviewed by a physicist and a physician.
† 68Ga (for diagnosis) and 177Lu-Dota (for therapy) both target cell surface somatostatin receptors (SSTCs) which are commonly expressed in NETs.
| Requirement | QIPCM Solution |
|---|---|
| Scanner QA at Various Sites | Scanner consultation & QA by QIPCM |
| Image Anonymization and Transfer from Multiple Institutions | Custom pipeline for de-identification and secure transfer from each institution to the QIPCM repository |
| Image QA | Image QA by QIPCM |
| Centralized Storage with Image Access Logs | Images that pass QA are forwarded to secure & backed up centralized PACS |
| Remote Connection (2-factor authentication) | QIPCM Virtual Desktop Infrastructure (VMs) |
| Remote Contouring | Installation of desired software onto user VMs (QIPCM-developed contouring workflow) |
| Personalized Dosimetry, Report Generation and Publishing | Installation of desired software onto user VMs (QIPCM-developed dosimetry plug-in) |
